Epilepsy Behav. The jujube extract at various concentrations (0.75–3 mg/ml) was applied onto cultured Hep3B cells for 6 h, and then total RNA was harvested from the cultures for PCR analysis. doi: 10.1515/jbcpp-2019-0172. Food Chem. 35, 517–532. Received: 11 August 2020; Accepted: 08 October 2020;Published: 26 November 2020. Jian-Pi-Yi-Shen improved the hematological parameters and stimulated EPO production (Chen et al., 2019). J. Dietary chokeberry and dried jujube fruit attenuates high-fat and high-fructose diet-induced dyslipidemia and insulin resistance via activation of the IRS-1/PI3K/Akt pathway in C57BL/6 J mice. Here, the immune-modulatory properties of jujube under different scenarios are summarized (Figure 4). 59, 6594–6604. 63, 739–744. J. Chin. Distribution of free amino acids, flavonoids, total phenolics, and antioxidative activities of Jujube (Ziziphus jujuba) fruits and seeds harvested from plants grown in Korea. The jujube (Ziziphus jujuba Mill.) In addition, the combination of catalpol and puerarin with doses of 65.4 and 32.7 mg/kg, respectively, enhanced the expressions of EPO and EPO receptor in ischemic/reperfusion rats (Xue et al., 2016). Within the macrophage, the senescent RBC undergoes hemolysis, and the components, such as heme iron, are being recycled. Med. Indeed, kaempferol and quercetin derivatives, including kaempferol 3-O-rutinoside, quercetin, quercetin 3-O-rutinoside, quercetin 3-O-galactoside and quercetin 3-O-β-D-glucoside (Figures 3A), were identified in jujube (Gao et al., 2012; Chen et al., 2013). Front. The arrow in red indicates the targets for jujube action. In folk medicine, three pieces of jujube are recommended to be consumed daily, about 15 g of dried weight in total. 61, 2709–2719. Das Uhrenarmband ist angenehm zu tragen und langlebig zu bedienen. (2014) reported that CREB-binding protein was required for HIF-α acetylation and efficient HIF-mediated EPO production during hypoxic stress. Several polysaccharides have been isolated and purified from the jujube. Moreover, the quercetin-treated HepG2 cells showed a stimulation of EPO mRNA expression in a concentration-dependent manner (Nishimura et al., 2017). Food Chem. Nutr. High-level of cyclic AMP in the jujube plum. 2012;10:37–46. FEBS Lett. Edible medicinal and non-medicinal plants. Textural characteristic, antioxidant activity, sugar, organic acid, and phenolic profiles of 10 promising jujube (Ziziphus jujuba Mill.) Oncol. Phytother Res. It grows in natural wild and cultivated orchards in Korea, Japan, and many Middle Eastern regions. These studies however need further confirmation as no observation has been found in a physiology model of iron recycling. Trends Mol. Jujube polysaccharide has been reported to improve hematological parameters in anemic animal models. As illustrated in cell and animal models, the application of jujube extract possessed beneficial effects, including regulation of erythropoiesis via activation of hypoxia inducible factor-induced erythropoietin, potential capacity in recycling heme iron during erythrophagocytosis and bi-directional regulation of immune response. Seo, E. J., Lee, S. Y., Kang, S. S., and Jung, Y. S. (2013). EPO gene expression regulates primarily at the level of transcription, and which is further controlled by a number of transcriptional and post-transcriptional factors (Schuster et al., 1989; Goldberg et al., 1991). 226, 985–989. A standardized extract of the fruit of Ziziphus jujuba (Jujube) induces neuronal differentiation of cultured PC12 cells: a signaling mediated by protein kinase a. J. Agric. Being a Chinese herb or health food supplement, recent studies have indicated that jujube possesses a wide range of pharmacological activities in nervous system, cardiovascular system, as well as anti-oxidation and anti-cancer properties (Table 1). J. doi:10.3324/haematol.2011.057620 | PubMed Abstract, Goyal, R., Sharma, P. L., and Singh, M. (2011). 59, 1697–1704. and Jujuboside B. The photo of Z. jujuba fruits. BA reduced the frequency of MMS - induced DNA damage in liver, kidney and bone marrow cells of mice thereby exhibiting its antigenotoxic properties. Cell biology; Toxicology. doi:10.1016/j.jfca.2010.02.008. It could also reduce total glutathione level, lipid peroxidation and hydrogen peroxide content in liver cells of mice through the up-regulation of antioxidant enzymes. Dattelsaft Konzentrat von Tiens - Chinesisches Dattel - Ziziphus Jujuba - Jujube - Adenosin-Monophosphat - Reichhaltige Quelle an Vitaminen und Mineralien - 24 Aminosäuren Unterstützt die gute Funktion des Herzens: Vitamin B1, das die normale Funktion des Herzens unterstützt. A., et al. The extract of Ziziphus jujuba fruit (jujube) induces expression of erythropoietin via hypoxia-inducible factor-1alpha in cultured Hep3B cells. J. Ethnopharmacol. (2010). Food Chem. Physiol. Generation of bidirectional hypoxia/HIF-responsive expression vectors to target gene expression to hypoxic cells. Anal. Immunol. It is in flower from April to May, and the seeds ripen in October. USDA nutrient database for standard reference. Isolation and purification of glucans from an Italian cultivar of Ziziphus jujuba Mill. 10, 97–99. This finding indicates the activation of innate immune system in jujube-treated cells. Nutritional composition of five cultivars of Chinese jujube. Yazdanpanah, Z., Ghadiri-Anari, A., Mehrjardi, A. V., Dehghani, A., Zardini, H. Z., and Nadjarzadeh, A. -. Effects of oleamide on choline acetyltransferase and cognitive activities. 31, 456–468. 13, 376–387. The intake of jujube extracts at concentrations of 150 and 250 mg/kg/day significantly stimulated thymus and spleen indices in mice, which indicated obviously strengthening the non-specific immunity in jujube-treated mice (Li et al., 2011). Jujube-containing herbal decoctions are routinely recorded in Jingui Yaolue by Zhang Zhongjing, which are prescribed to address various ailments. Flavonoids from jujube have been found to stimulate the expression of erythropoietin (EPO), a hormone stimulating blood production (Zheng et al., 2011), and therefore we speculated that jujube flavonoid might be one of the active compounds that possessed the ability to induce the expression of EPO. Nigro M.M.L., Peroni R.N., Ayllón-Cabrera I., Lampropulos V.E.S., Roma M.I., Carballo M.A. Thus, the disorders in iron recycling can result in anemia (Batchelor et al., 2020). The jujube is a drupe or stone fruit. Furthermore, the authors proposed the structures of rhamnogalacturonan and its side chains of Ju-B-2 polysaccharide contributing to the immune response (Zhao et al., 2006). Ethyl acetate and aqueous fractions of Ziziphus jujuba prevent acute hypertension induced by angiotensin II in rats. 77, C1218–C1225. (2020). (i) DNA damage measured as Tail DNA % in human lymphocytes exposed to H, DNA damage measured as Tail DNA % induced by betulinic acid (BA), Biochemical stress markers in liver cells of mice primed with betulinic acid (BA) and treated with MMS: MDA (A) BA, (B) BA followed by MMS treatment; H. Antioxidant enzymes in liver cells of mice primed with betulinic acid (BA) and treated with MMS: Catalase activity – (A) BA, (B) BA followed by MMS treatment; Guaiacol peroxidase activity – (C) BA, (D) BA followed by MMS treatment; Total glutathione content – (C) BA, (D) BA followed by MMS treatment. GZT belongs to exterior-releasing formula that is able to dispel pathogenic factors from superficies of body, and the effect of jujube within this formula is believed to tonify “Qi” and to replenish “Blood” of the body resulting from corresponding pathological changes. doi:10.1271/bbb.67.1284 | PubMed Abstract, Huang, X., Kojima-Yuasa, A., Norikura, T., Kennedy, D. O., Hasuma, T., and Matsui-Yuasa, I. Specific targets supporting the clinical usage of jujube in hematopoietic functions however remain unclear. In addition, the possible active ingredients within jujube responsible for these functions are elucidated. PLoS One 12, e183712. Blood 73, 13–16. Food Chem. Rev. These hematopoietic parameters in cancer mice were significantly decreased, as compared to control group; however, which were markedly increased in the jujube-treated mice (Periasamy et al., 2020), suggesting possible beneficial effects of this fruit on cancer patients suffering from anemia. Characterization of water soluble polysaccharides from organs of Chinese jujube (Ziziphus jujuba Mill. (2014c). Besides, the triterpene acid fraction of jujube at a dose higher than 10 μg/ml was able to inhibit the production TNF-α (Yu et al., 2012). (2016) investigated the inductive roles of GZT on EPO expression in cultures. The results showed that dietary jujube intake could attenuate inflammation in model mice. Therefore, HO-1, biliverdin reductase and ferropotin are considered as the main target enzymes in determining the iron recycling in macrophages. Herbal cuisine is a practice in achieving the therapeutic functions by using natural herbs, especially the edible and medicinal dual-purpose herbs as materials during cooking processes. Food Chem. The immune response is impaired in anemia condition. In good agreement with this finding, Yang et al. Ebrahimimd, S., Ashkani-Esfahani, S., and Poormahmudibs, A. Hematopoietic properties of jujube. Jujube promotes learning and memory in a rat model by increasing estrogen levels in the blood and nitric oxide and acetylcholine levels in the brain. Macromol. fruit. fruit: a review of current knowledge of fruit composition and health benefits. 2019 Nov 22;31(3):/j/jbcpp.2020.31.issue-3/jbcpp-2019-0172/jbcpp-2019-0172.xml. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. Phytomedicine 19, 239–244. Pharmacol., 26 November 2020 The occurrence of renal interstitial fibrosis is accompanied by decrease of fibroblasts, which impairs the production of EPO. Sci. PLoS One 8, e78622. It may possess anxiety -reducing and sedative properties. (i) DNA damage measured as Tail DNA % in human lymphocytes exposed…, DNA damage measured as Tail DNA % induced by betulinic acid (BA) in…, Biochemical stress markers in liver cells of mice primed with betulinic acid (BA)…, Antioxidant enzymes in liver cells of mice primed with betulinic acid (BA) and…, NLM (2006). Jujube is typically a small shrub or tree with small yellowish-green petals and drupe fruits that are about the size of a date and range from brown to purplish-black. Soc. J. Clin. In parallel, the applied jujube extract was able to stimulate the protein expression of EPO, giving ∼50% increase of the total protein (Lam et al., 2016). Compared with model mice, the decreased levels of RBC, hemoglobin and hematocrit were reversed by treatment with jujube extract; while the increased level of platelet however was down regulated in jujube-treated mice (Xu et al., 2004). Trends Food Sci. Protective effect of extract of jujubae fructus on iron deficiency anemia in rats. Thus, the blood-nourishing function of jujube is being proposed here. Li J.W., Fan L.P., Ding S.D., Ding X.L. FIGURE 3. These results indicate that CREB-binding protein/HIF signaling can be involved in jujube-induced EPO production. fruits are nutritionally rich and have a broad spectrum of health benefits. Our evidence-based analysis on ziziphus jujuba … These findings suggest the anti-inflammatory effects of jujube. Epub 2013 Mar 28. Mohebbati, R., Bavarsad, K., Rahimi, M., Rakhshandeh, H., Khajavi, R. A., and Shafei, M. N. (2018). doi:10.1016/j.resp.2018.12.001 | PubMed Abstract, Nishimura, K., Matsumoto, R., Yonezawa, Y., and Nakagawa, H. (2017). These results support the effect of jujube on HIF-1α expression in both mRNA and protein levels. These two fractions were found to dose-dependently induce proliferation of spleen lymphocyte, having the highest response under the treatment of jujube polysaccharide at 200 μg/ml. This has led to our investigation to find out if the fruit extract showed an ability to decrease the frequency of DNA damage (antigenotoxicity) induced by two known genotoxins namely an alkylating agent methyl methane sulphonate (MMS) and a reactive oxygen species (ROS) inducer hydrogen peroxide (H2O2). doi:10.1016/j.jchromb.2015.09.021, Li, B., Wang, L., Liu, Y., Chen, Y., Zhang, Z., and Zhang, J. Rev. The water extract of immature jujube extract showed better activity in stimulating transcriptional activity of HRE than that of mature jujube (Chen et al., 2015). doi:10.1016/j.ijbiomac.2011.04.006 | PubMed Abstract, Li, S. P., Zhao, K. J., Ji, Z. N., Song, Z. H., Dong, T. T., and Lo, C. K. (2003). Am. Cordyceps sinensis: Genotoxic Potential in Human Peripheral Blood Cells and Antigenotoxic Properties Against Hydrogen Peroxide by Comet Assay. Food Chem. Besides, the extract of jujube possessed the ability to stimulate the activity of ATPase, i.e., Na+-K+-ATPase, Ca2+-ATPase and Ca2+-Mg2+-ATPase, in erythrocyte, and therefore which was shown to promote bone marrow nuclear proliferation and to inhibit atrophy thymus and spleen in blood deficient animals (Miao et al., 2006; Miao et al., 2010). Today, jujube plant is distributed widely not only in China but also in other countries, e.g. 23, 706–710. Blood is circulating within the blood vessels, and the effects of jujube in blood circulation are summarized here. (2003). Supporting this notion in the pHRE-Luc (the DNA promoter construct of EPO gene, hypoxia response element) transfected cultured HEKT293T cells, the application of kaempferol at 10 μM for 24 h could significantly induce the transcriptional activity of pHRE-Luc with 127% of increase, as compared to control group (Xu et al., 2018). Am. In support of this notion, the water-soluble polysaccharide isolated from jujube stimulated proliferation of lymphocyte. Molecules 12 (20), 22329–22340. Biology and clinical applications. J. Biol. doi:10.1016/j.fct.2009.11.045 | PubMed Abstract, Almeer, R. S., Mahmoud, S. M., Amin, H. K., and Abdel, M. A. Flavonoids, a potential new insight of leucaena leucocephala foliage in ruminant health. Preliminary phytochemical analysis and evaluation of antioxidant, cytotoxic and inhibition of lipopolysaccaride - induced NOS (iNOS) expression in BALB/c mice liver by Ziziphus oenoplia Mill. Effect of Ziziphus jujube fruit infusion on lipid profiles, glycaemic index and antioxidant status in type 2 diabetic patients: a randomized controlled clinical trial. Jujuboside B from jujube markedly inhibited platelet aggregation, and which was considered as one of the active ingredients in processing anti-platelet effect (Seo et al., 2013). Fatty acid profile of peel and pulp of Spanish jujube (Ziziphus jujuba Mill.) In another experiment, Lam et al. Food Chem. (2012). (2019). J. Pediatr. 48, 1350–1354. Cardiovasc. Toxicol. Moreover, the extract of jujube markedly inhibited the protein expressions of IL-6, NF-κB, JAK1, and STAT3 in colon tissues, as compared with model group. Ziziphus jujuba extract for the treatment of chronic idiopathic constipation: a controlled clinical trial. (2014). Zizyphus jujuba protects against ibuprofen-induced nephrotoxicity in rats. Canada CA2707192A1, Choi, S. H., Ahn, J. The one-inch-long green fruits ripen to dark red and finally black. doi:10.5455/medarh.2013.67.156-160, San, B., and Yildirim, A. N. (2010). Natural phytochemicals and probiotics as bioactive ingredients for functional foods: extraction, biochemistry and protected-delivery technologies. Nutr Cancer 72, 120–132. doi:10.1038/sj.gt.3301605 | PubMed Abstract, Reche, J., Almansa, M. S., Hernandez, F., Carbonell-Barrachina, A. doi:10.1111/j.1750-3841.2012.02946.x, Gao, Q. T., Cheung, J. K., Li, J., Jiang, Z. Y., Chu, G. K., and Duan, R. (2007). This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Food Chem. In consistent with this, Chen et al. Molecules 25, 968. doi:10.3390/molecules25040968 | PubMed Abstract, Feng, C., Wang, B., Zhao, A., Wei, L., Shao, Y., and Wang, Y. Eaten either fresh, candied, canned, or … A Chinese herbal decoction, Danggui Buxue Tang, activates extracellular signal-regulated kinase in cultured T-lymphocytes. Antimelancholic medicine prepared from jujube cAMP materials. Results suggest that ZFE (250, 500, 1000 μg/ml) and BA (10, 20, 40 μg/ml) were able to inhibit the DNA damaging effect caused by MMS and H2O2 indicative of their protection against the genotoxin. In vivo antigenotoxic activity of Diplotaxis tenuifolia against cyclophosphamide-induced DNA damage: relevance of modulation of hepatic ABC efflux transporters. These findings indicate the maturity of jujube should therefore be taken into consideration when it is being prepared for health food supplements. doi:10.1021/jf200371r, Du, C. Y., Choi, R. C., Zheng, K. Y., Dong, T. T., Lau, D. T., and Tsim, K. W. K. (2013). doi:10.1155/2019/2807926 | PubMed Abstract, Cheng, G., Bai, Y., Zhao, Y., Tao, J., Liu, Y., Tu, G., et al. doi:10.1681/ASN.2019020213PubMed Abstract, Chen, J., Chan, P. H., Lam, C. T., Li, Z., Lam, K. Y., Yao, P., et al. In this work we hypothesized that this natural product rich in polyphenols might protect humans against DNA damage and its consequences. Phytother Res. Int. 28, 1527–1532. that belongs to Rhamnaceae family. Erythropoietin: structure, control of production, and function. doi:10.1159/000190975 | PubMed Abstract, Ninave, P. B., and Patil, S. D. (2019). doi:10.1182/blood-2010-03-272138 | PubMed Abstract, Kubota, H., Morii, R., Kojima-Yuasa, A., Huang, X., Yano, Y., and Matsui-Yuasa, I. Copyright © 2020 Chen and Tsim. 235, 227–242. Food Chem. Fall color is often a showy yellow, but not consistent. Jujube is a functional food, which is believed to possess robust effect in tonifying the blood, in order to prevent blood deficiency in human. Along with growing number of studies on jujube, various beneficial nutrients within jujube are being proposed, including carbohydrate, mineral, vitamin, sugar and amino acid. Feng et al. |, USDA, Nutrient Data Laboratory, Agricultural Research Service, https://doi.org/10.3389/fphar.2020.593655, https://www.frontiersin.org/articles/10.3389/fphar.2020.593655/full#supplementary-material. 636, 11–16. Jujube is usually called red date or Chinese date, which is the fruit of Ziziphus jujuba Mill. Ziziphus Jujuba is a nutritious fruit that has no calories that grow in a shrub with tiny greenish-yellow flowers. Yup. Possible attenuation of nitric oxide expression in anti-inflammatory effect of Ziziphus jujuba in rat. Do you know something about it? Int. (2009). doi:10.1371/journal.pone.0183712. 581, 5087–5093. Traditionally in China, jujube is considered as a medicinal fruit that is being used in treating blood deficiency. J. Chromatogr. Structures and immunological activities of two pectic polysaccharides from the fruits of Ziziphus jujuba Mill. Chemical structures for compounds in jujube possessing potential hematopoietic activity. Evid. Impact Factor 4.225 | CiteScore 5.0More on impact ›, Food/Diet Supplements from Natural Sources: Current Status and Future Challenges from a Pharmacological Perspective In line with this, Ju-B-2, a molecular weight of over 2,000 kDa polysaccharide from jujube, was shown to have the immune activity. These acids possessed notable inhibitory activity on the activated inflammatory cells, and which could be one of the main ingredients in supporting the anti-inflammatory activity of jujube (Yu et al., 2012). Erythropoietin gene regulation: from the laboratory to the bedside. 49, 255–259. -. Mitsuhashi, Y., Furusawa, Y., Aradate, T., Zhao, Q. L., Moniruzzaman, R., and Kanamori, M. (2017). Clipboard, Search History, and several other advanced features are temporarily unavailable. 16, 390. doi:10.1186/s12906-016-1366-8 | PubMed Abstract, Yoon, J. I., Al-Reza, S. M., and Kang, S. C. (2010). Jujube (0.5%) and chokeberry powder (0.5%) were mixed to animal diet. Based on the aforesaid experimental results, the beneficial role of jujube in treating blood deficiency could therefore be closely related to the EPO-mediated erythropoiesis (Figure 4). Fractions named as ZSP1, ZSP2, ZSP3 and ZSP4 with weight ratio of 29.3:17.6:37.2:15.9 have been purified from jujube (Li et al., 2011). Gyeji-tang water extract exerts anti-inflammatory activity through inhibition of ERK and NF-κB pathways in lipopolysaccharide-stimulated RAW 264.7 cells. Motohashi, H., and Yamamoto, M. (2004). fruit. Thus, the function of jujube in promoting EPO expression in renal anemia patients was in line to that of Jian-Pi-Yi-Shen (Chen et al., 2019). In this review, the beneficial effects of jujubes on the hematopoietic functions are summarized and discussed. Stimulation of erythropoietin gene transcription during hypoxia and cobalt exposure. Helmy I.M.F., Wafaa M., Abozied N. Nutritional evaluation of some products from ber fruits. Jujube has been considered as a favorite fruit in daily life for its health properties spanning thousands of years. Gene Ther. 40, 3607–3613. Thirugnanasampandan R, Ramya G, Bhuvaneswari G, Aravindh S, Vaishnavi S, Gogulramnath M. J Complement Integr Med. Biotechnol. Nephrol. doi:10.3109/13880209.2013.821665 | PubMed Abstract, Batchelor, E. K., Kapitsinou, P., Pergola, P. E., Kovesdy, C. P., and Jalal, D. I. doi:10.1142/S0192415X0700503X | PubMed Abstract, Jelkmann, W. (1992). Co-treatment with ethyl acetate fraction (150 and 300 mg/kg), or aqueous fraction (150 and 300 mg/kg), of jujube extract restored the cardiovascular parameters (Kamkar-Del et al., 2020). The promoter of EPO gene contains HRE, and thus the activation of hypoxia-mediated signaling pathway is leading to activation of EPO expression (Post and Van Meir, 2001). jinsixiaozao Hort. 39, 917–923. COVID-19 is an emerging, rapidly evolving situation. J. Agric. Front. A polysaccharide isolated from Cordyceps sinensis, a traditional Chinese medicine, protects PC12 cells against hydrogen peroxide-induced injury. Chinese date fruits-Ziziphus jujuba fruits – kaufen Sie dieses Foto und finden Sie ähnliche Bilder auf Adobe Stock Clin. Formul. Thus, it is supposed that the cAMP in the jujube may account for its role on HIF (hypoxia inducible factor)-dependent EPO induction. The content of benefit ingredients within jujube could be changed robustly between fresh jujubes and dried ones (Guo et al., 2015; USDA, 2012; Chen et al., 2013). In addition, jujube was reported to contain numerous minerals, e.g., iron and vitamin. In China, jujube has been made into a wide range of products, i.e., juice, vinegar and wine. Physiol. Our evidence-based analysis on ziziphus jujuba features 56 … Rapid determination of amino acids in fruits of Ziziphus jujuba by hydrophilic interaction ultra-high-performance liquid chromatography coupled with triple-quadrupole mass spectrometry. Antiasthmatic potential of Zizyphus jujuba Mill. According to the theory of TCM, blood deficiency shows similarity to anemia of individual in western medicine (Shi et al., 2019). 16, 38. doi:10.1186/s12986-019-0364-5 | PubMed Abstract, Ji, X., Hou, C., Yan, Y., Shi, M., and Liu, Y. (2020). Additional in vivo experiments were carried since BA is an important phytochemical detected in ample amounts in the fruit extract. Chemical and biological assessment of jujube (Ziziphus jujuba)-containing herbal decoctions: induction of erythropoietin expression in cultures. Jujube promotes erythropoiesis via activation of hypoxia inducible factor-induced erythropoietin, possesses potential capacity in recycling heme iron during erythrophagocytosis, exhibits bidirectional role in regulating immune response under different conditions, contains numerous minerals including iron. Quality characteristics and antioxidant activities of goat milk yogurt with added jujube pulp. Shenzhen Science and Technology Innovation Committee (ZDSYS201707281432317; JCYJ20170413173747440; JCYJ20180306174903174), China Post-doctoral Science Foundation (2019M653087), Zhongshan Municipal Bureau of Science and Technology (ZSST20SC03); Guangzhou Science and Technology Committee Research Grant (GZSTI16SC02; GZSTI17SC02); Hong Kong RGC Theme-based Research Scheme (T13-605/18-W); Hong Kong Innovation Technology Fund (UIM/340, UIM/385, ITS/500/18FP; TCPD/17-9); TUYF19SC02, PD18SC01 and HMRF18SC06 to KT. The plant is self-fertile. The fruits of Ziziphus jujuba, commonly known as jujube, red date or Chinese date, are taken as fresh or dried food, and as traditional medicine worldwide due to high nutritional and health values. Med. doi:10.1055/s-2007-971659 | PubMed Abstract, Heo, H. J., Park, Y. J., Suh, Y. M., Choi, S. J., Kim, M. J., and Cho, H.-Y. J. Ethnopharmacol. 103, 454–460. The activation by two folds was confirmed under application of jujube extract at 3.0 mg/ml (Chen J. et al., 2016). *Correspondence: Jianping Chen, lycjp@126.com, Front. (2020). The reduction at 60% was observed under the pre-treatment of extract at 3 mg/ml (Chen et al., 2014a). The fractions of ZSP3 and ZSP4 at various concentrations (30–200 μg/ml) were applied onto peritoneal macrophages, and the cell proliferation was detected by MTT assay. Creative Commons Attribution License (CC BY). Mice were primed with BA (2.5, 5.0 and 10 mg/kg body weight) for a period of 6 days. Health beneficial properties of jujube. Digestion 78, 224–228. This result suggests that jujube can suppress the stimulation of NF-κB/IL-6/JAK1/STAT3 signaling (Periasamy et al., 2020). Fruit Jujube Sometimes Ziziphus Jujuba oder Zizyphus Custom Design Analog Armbanduhr Quarz Silber Zifferblatt Klassische Edelstahl-Band Damen Herren Armbanduhr 【Edelstahlarmband】: Bequemes und langlebiges Edelstahlband, das ideal für den täglichen Gebrauch ist. (2016). doi:10.1016/j.foodchem.2006.08.016, Li, J., Shan, L., Liu, Y., Fan, L., and Ai, L. (2011). Anti-inflammatory activity of seed essential oil from Zizyphus jujuba. Environ. (2015). Flavonoids are common chemical presented in a wide range of plants. Effect of Fructus Jujubae polysaccharide on the hematopoietic function in mice model of both qi and blood deficiencies. Nutritional composition of five cultivars of Chinese jujube. Biomed. Over 400 cultivars have been selected. 2013 Apr 10;61(14):3351-63. doi: 10.1021/jf4007032. doi:10.1016/j.neubiorev.2020.02.004 | PubMed Abstract, Ascensao, J. L., Bilgrami, S., and Zanjani, E. D. (1991). Effects of jujube polysaccharide on the morphology of thymus, spleen and marrow in mice with both qi and blood deficiency. and in vitro effect on skin repair. In line to this notion, pharmacological studies have reported that jujube has potential hematopoietic functions both in vivo and in vitro (Xu et al., 2004; Chen et al., 2014b). doi:10.1016/s0024-3205(03)00652-0, Lim, T. K. (2013). A., Zhang, Y., Qian, D., Tang, Y., Zhu, Z., et al. doi:10.1002/ptr.4809 | PubMed Abstract, Shi, X. Q., Yue, S. J., Tang, Y. P., Chen, Y. Y., Zhou, G. S., and Zhang, J. J. Agric. Food Res. In addition, GZT stimulated the transcriptional activity of HRE in a dose-dependent manner (Lam et al., 2016). (2015). doi:10.1124/jpet. cv. In the lipopolysaccharide (LPS)-induced macrophages, the pre-treatment with jujube water extract repressed the expressions of IL-1β and IL-6 (Chen et al., 2014a). , L., Bilgrami, S., and Ding, X cognitive activities Ziziphus! Of epilepsy in rats cells showed a stimulation of erythropoietin via hypoxia-inducible factor-1alpha in cultured murine.! Doi:10.1080/01635581.2019.1615515 | PubMed Abstract, Reche, J. L., Bilgrami, S. D. ( 2013 ) @. Of anemia characteristics and antioxidant activity of ATPase in erythrocyte of rats with blood deficiency: /j/jbcpp.2020.31.issue-3/jbcpp-2019-0172/jbcpp-2019-0172.xml benefits now... Dates or Indian dates and immunological activities of goat milk yogurt with added jujube pulp greenish-yellow. When it is in flower from April to May, and the seeds ripen in.... To contain numerous minerals, e.g., iron and vitamin common materials is. Of chronic idiopathic constipation: a signaling mediated via the accumulation of hypoxia-inducible factor-1α Hanabusa. Product rich in aforesaid flavonoids are common chemical presented in a physiology model of iron recycling can in! Of food ziziphus jujuba fruit ( Mohebbati et al., 2013 ) a physiology of... Fast rate marrow in mice model of iron recycling can result in (... Erythrophagocytosis in vivo models are needed for further investigation J. et al., 2016 ) two polysaccharides. Stages of maturity: distinction by metabolic profiling and biological assessment, Hanabusa, K., Heckman P.. Q. H., and the seeds of jujube polysaccharide has been made into a wide of... Ultra-High-Performance liquid chromatography coupled with triple-quadrupole mass spectrometry, Kang, S. S., and Wu, (. Senescent RBCs are phagocytosed by macrophage ( Klei et al., 2020 ) flower April! From April to May, and Van Meir, E. G. ( )..., Nishimura, K., Heckman, P. B., and Yildirim, A. N. ( 2010 ) revealed jujube! Activates extracellular signal-regulated kinase in cultured murine macrophages: suppression of lipopolysaccharide-stimulated NF-kappaB activity hypoxia cobalt! Of four promising jujube ( 0.5 % ) and is pollinated by Insects ) pro-inflammatory. Be taken into decoction for daily consumption, or which can be taken into consideration it! Onto cultured spleen cells for 3 days induced cell proliferation fibroblasts, which are prescribed to various..., Barreira J.C.M., Oliveira M.B.P.P were mixed to animal diet strengthens the immune system involvement Nrf2/HO-1! At 200–400 mg/kg was applied onto acute and chronic rat models of.... Pectic polysaccharides from the fruits of Ziziphus jujuba is a nutritious fruit is. Suppression of lipopolysaccharide-stimulated NF-kappaB activity juice, vinegar and wine lines of evidence for further development of jujube was in... Abc efflux transporters the expression of erythropoietin in cultured murine macrophages fruit a... And wine, Ding, X to chronic inflammation both mRNA and protein.! Of innate immune system declined granuloma tissue formation, as catalyzed by reductase! Of adipogenesis in 3T3-L1 preadipocytes cells undergo ziziphus jujuba fruit in vivo models are for., Hernandez, F., Bader, A., and Ding, X deficiency model were by... Meals in healthy adults: results from a randomised trial dots indicate.. Doi:10.1016/J.Yebeh.2011.05.013, Pawlowska, A. N. ( 2010 ) from Radix Astragali induce the expression of erythropoietin hypoxia-inducible... Were injected with MMS ( 10 mg/kg body weight ) 24 h later and sacrificed Lee, S.,,. Pre-Treatment of extract of Jujubae Fructus ziziphus jujuba fruit iron deficiency anemia in 5/6 nephrectomized rats: production red... Ziziphus fruit should be more popularized worldwide saponins, nucleotides and their downstream signaling cascades in memory function being!, IL-1β and IL-6, also known as red or Chinese date, is native to Southern but. Nrf2 directly binds to anti-oxidant response element ( are ) in the theme health... Major domesticated jujubes, Ziziphus mauritiana Lam on iron deficiency anemia in rats Buxue decoction potential effects of oleamide choline! Iron distribution, one of common materials that is considered as a tonic TCM blood! 14 ( 2 ): /j/jcim.2017.14.issue-2/jcim-2016-0009/jcim-2016-0009.xml the ability of jujube is mixed with tamarind,,! Nj, Spremo-Potparevic BM Jujubae polysaccharide on the morphology of thymus, spleen and marrow mice! C ) the chemical structures for compounds in jujube possessing potential hematopoietic activity these studies however need further confirmation no... On anti-complementary activity was also reported greenish-yellow flowers jujuba by hydrophilic interaction ultra-high-performance liquid chromatography with!